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TACE联合瘤内注药治疗中晚期肝癌的疗效观察
作者:陈德连  徐雪明  陈明聪  尚岩  林琪 
单位:台州市肿瘤医院  浙江 台州 317502 
关键词:肝肿瘤/药物疗法 导管插入术 碘化油/治疗应用 化学栓塞 治疗性 乙醇/治疗应用 药物疗法 联合 随机对照试验 治疗结果 
DOI:R735.7;R730.53
出版年,卷(期):页码:2012,27(2):171-174
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摘要:
目的 评价瘤内注射碘化油混悬液和无水乙醇联合肝动脉化疗栓塞术(TACE)治疗中晚期肝癌的疗效。方法 61例中晚期肝癌随机分为联合介入组(实验组)与TACE组(对照组),组间比例是1:1,实验组采取瘤内注射碘化油混悬液和无水乙醇联合TACE术,对照组则单纯采取TACE术,比较两组之间的总有效率,无进展生存期,总生存率和不良反应。结果 实验组的总有效率明显优于对照组(64.5% vs 40.0%,P=0.049);治疗和对照组中位无进展生存期(PFS)分别为10月和7月(χ2=4.821,P=0.028),中位生存时间(MST)分别为17月和14月(P=0.061)。两组均未出现严重的不良反应。结论 瘤内注射碘化油混悬液和无水乙醇联合肝动脉化疗栓塞术(TACE)治疗可增加肿瘤有效率,延缓肿瘤进展时间,不良反应可耐受。
Objective To evaluate the efficacy of transcatheter arterial chemoembolization (TACE) combined with intratumoral injection of iodized oil and ethanol for middle-advanced stage hepatocellular carcinoma (HCC). Methods Sixty-one patients with middle-advanced stage HCC were randomized into trial and control groups. Patients in trial group were treated by TACE combined with intratumoral injection of iodized oil and ethanol; those in control group were treated by TACE alone. The overall response rate, progression free survival (PFS) and media survival tiem(MST) were compared between two groups. Results The overall response rate in trial group was significantly higher than that in control group (64.5% vs 40.0%, P=0.049). The PFS rate in trial group and in control group was 10 months and 7 months(χ2=4.821, P=0.028), respectively. The MST in trial group and in control group was 17 months and 14 months(P=0.061), respectively. No serious complications were observed in both groups. Conclusion TACE combined with intratumoral injection of iodized oil and ethanol may increase the overall response rate and prolong tumor progression time in patients with middle-advanced stage hepatocellular carcinoma.
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