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甘氨双唑钠增敏食管癌后程加速超分割放疗协同化疗的临床研究
作者:赵兴  周毛  王立平  常巧梅  安生花  王晓莉  刘晓刚  祁艳娟  陈凡 
单位:青海大学附属医院放疗科  青海 西宁 810001 
关键词:食管肿瘤/药物疗法 食管肿瘤/放射疗法 辐射增敏药/治疗应用 辐射剂量 随机对照试验 综合疗法 治疗结果 
DOI:R735.1/R730.53
出版年,卷(期):页码:2012,27(4):358-361
摘要:
目的 观察甘氨双唑钠增敏后程加速超分割协同化疗治疗食管癌的近期疗效,研究和探讨放(化)疗增敏剂、化疗药物、放疗剂量分割方式及三者联合应用的机制。方法 将60例病理证实、各期、未进行过任何治疗的食管癌患者随机分为甘氨双唑钠增敏后程加速超分割放疗结合化疗的试验组(LCAHR+C+CMNa)和单纯后程加速超分割放疗结合化疗的对照组(LCAHR+C),分别采用上述两种方法治疗,在治疗前、治疗第4周和治疗后分别行CT或X线片检查,根据摄片进行肿瘤大小的测量,比较两种方法治疗肿瘤的近期疗效。结果 对照组有效22例,无效8例;试验组有效28例,无效2例,试验组近期疗效优于对照组(P < 0.05),两组患者不良反应发生率比较差异无统计学意义(P > 0.05)。结论 用甘氨双唑钠增敏后程加速超分割协同化疗的方法治疗食管癌近期疗效显着,不良反应可以耐受。
Objective To evaluate the short-term efficacy of late course accelerated hyperfractionated radiotherapy combined with radiosensitizer glycodidazolium natrium (CMNa) plus concurrent chemotherapy for patients with esophageal carcinoma (n=30 in each group) and to investigate the related mechanism. Methods Sixty patients with pathologically approved and untreated esophageal carcinoma in varions stages were randomly assigned to receive late course accelerated hyperfractionated radiotherapy combined with CMNa plus concurrent chemotherapy (LCAHR + C + CMNa group) or late course accelerated hyperfractionated radiotherapy combined with concurrent chemotherapy(LCAHR + C group). Tumor size was measured by CT scan or X-ray before, in the 4th week of and after the treatment. The short-term efficacy was evaluated. Results The short-term effective rate of LCAHR + C + CMNa and LCAHR + C groups was 93.3% (28/30) and 73.3% (22/30), respectively; the difference was statistically significant (P < 0.05). There were no significant differences in adverse reaction rate between two groups (P > 0.05). Conclusion Radiosensitizer glycodidazolium natrium may enhance the short-term efficacy of LCAHR + C in patients with esophageal carcinoma and the side effects are tolerable.
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