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涎腺基底细胞腺瘤临床病理分析
作者:赵雪艳  荣小伟  田海萍  徐远义 
单位:1. 宁夏医科大学病理教研室  宁夏 银川 750004 
2.
 延安市人民医院病理科  陕西 延安 716000 
3.
 宁夏医科大学附属总院病理科  宁夏 银川 750004 
关键词:肿瘤 基底细胞/病理学 涎腺 诊断 鉴别 免疫组织化学 
DOI:R781.7
出版年,卷(期):页码:2012,27(5):514-517
摘要:
目的 探讨涎腺基底细胞腺瘤的临床病理特点、免疫表型、鉴别诊断、治疗及预后。方法 回顾性分析14例涎腺基底细胞腺瘤的临床资料、组织病理及免疫表型。结果 (1)涎腺基底细胞腺瘤好发于中老年女性,主要见于腮腺,生长缓慢,有完整包膜。(2)肿瘤由两种形态不同的基底样细胞混合而成,排列呈巢状、小梁状、腺管状,外周瘤细胞呈典型的栅栏状排列,并见明显的基底膜。(3)免疫组织化学:实体团块、小梁中央及管状结构的腔面细胞CK-pan(+),实体团块、小梁和小管的外周细胞p63(+),SMA(+),GFAP(-),Ki-67增值指数较低。结论 涎腺基底细胞腺瘤是一种少见肿瘤,但其具有一定临床病理特征及免疫表型,有利于诊断。诊断时需与基底细胞腺癌、腺样囊性癌,多形性腺瘤、基底样鳞状细胞癌鉴别,手术切除后预后较好。
Objective To investigate the clinicopathological features, immunoprofile, differential diagnosis, therapy and prognosis of basal cell adenoma of salivary gland. Methods The clinical, pathologic and immunohistochemical features of 14 cases with basal cell adenoma of the salivary gland were reviewed. Results (1) This neoplasm was usually occurred in parotid gland and had a definite predilection for middle and aged women patients, and the growth of the tumor was usually slow, and it had complete capsule. (2) It was composed of basaloid cells which had two different morphologies and intermingled with the patterns showing solid, trabecular and tubular. The peripheral cells showed a typical palisading with distinct basement membrane-like structure. (3) Immunohistochemistry staining for CK-pan expression was positive in the solid, trabecular and tubular central cells, p63 and SMA were positive in the solid, trabecular and tubular peripheral cells, GFAP was negative, Ki-67 presented a low level proliferation index. Conclusions Basal cell adenoma of the salivary gland is a rare tumor, but it has a certain clinicopathological features and immunoprofile which conduce to the diagnosis. The differential diagnosis involved basal cell adenocarcinoma, adenoid cystic carcinoma, pleomorphic adenoma and basaloid squamous cell carcinoma. The tumor has cften better prognosis after surgical ablation.
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