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食管胃结合部腺癌术后患者预后的相关因素研究
作者:王洪建  杨帆  姜振宇 
单位:滕州市中心人民医院肿瘤二科  山东 滕州 277500 
关键词:食管肿瘤/外科学 食管肿瘤/病理学 胃肿瘤/外科学 胃肿瘤/病理学 腺癌 基因 erbB-2 预后 肿瘤分期 存活率分析 淋巴转移 随访研究 
DOI:R735.1;R730.56
出版年,卷(期):页码:2014,29(2):173-174
摘要:
目的 研究食管胃结合部腺癌术后患者预后的相关因素。方法 入选食管胃结合部腺癌患者173例,从手术结束开始随访5年为研究终点,统计患者的1、3、5年生存率和中位生存时间。分析年龄、性别、淋巴结转移、是否化疗、HER-2表达与否等因素与该病的相关性。结果 经过5年随访,食管胃结合部腺癌患者在1、3、5年的生存率分别为87.9%、48.6%、44.5%,中位生存期为38.0月。分别统计和分析患者的各项因素,其中性别(P=0.000)、年龄(P=0.012)、TNM分期(P=0.000)、淋巴结转移(P=0.000)、化疗(P=0.000)、HER-2表达(P=0.000)等因素的差异均具有统计学意义。结论 食管胃结合部腺癌患者术后生存期与性别、年龄、TNM分期、淋巴结转移、是否化疗、HER-2表达均有不同程度的关联,值得进一步研究。
Objective To study the factors related to the prognosis of patients with adenocarcinoma in gastroesophageal junction after operation.Methods A hundred and seventy three patients diagnosed as adenocarcinoma in gastroesophageal junction were enrolled.The study started from the end of operation, and ended in the fifth year after operation.1-,3-,5-year survival rates and median survival time were collected.The association of age, gender, lymph node metastasis, chemotherapy, HER-2 expression and the disease was analyzed.Results After 5 years of follow-up, 1-, 3-, 5- year survival rates of patients with adenocarcinoma in gastroesophageal junction were 87.9%,48.6%,44.5%, respectively, and the median survival period was 38.0 months.Gender(P=0.000), age (P=0.012), TNM staging (P=O.000), lymph node metastasis (P=0.000), chemotherapy (P=0.000) and the expression of HER-2 (P=0.000) were associated with median survival time.Conclusion Gender,age,TNM stage,lymph node metastasis, chemotherapy, and HER-2 expression are all associated with median survival time in patients with adenocarcinoma in gastroesophageal junction.
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