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瘤内注射榄香烯乳治疗肝癌的疗效观察
作者:陆青媛  赵砚峰  张支农 
单位:1. 湖湘中医肿瘤医院肿瘤内科  湖南 长沙 417000 
2.
 湖湘中医肿瘤医院肿瘤外科  湖南 长沙 417000 
关键词:肝肿瘤/药物疗法 倍半萜类/投药和剂量 超声检查 介入性 穿刺术 注射 病灶内 静脉输注 
DOI:R735.7;R730.53
出版年,卷(期):页码:2014,29(3):263-266
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摘要:
目的 观察超声引导下经皮肝穿刺瘤体内注射榄香烯乳注射液治疗肝癌的疗效,以探讨本法的临床应用价值。方法 59例肝癌病例分为瘤体内注射榄香烯乳注射液(研究组)26例和静脉输注榄香烯乳注射液(对照组)33例,治疗3周期(每周期21天)后观察疗效,分析治疗后瘤体大小和生活质量状况。结果 研究组肿块缩小率及肿块回声增强率均高于对照组(57.7%、76.9% vs 24.2%、30.3%,均P<0.001),瘤体内血流信号减少率、瘤体内血流峰值流速减低率和瘤体内血流阻力指数减低率亦高于对照组(61.5%、34.6%、34.6% vs 30.3%、18.2%、21.2%,均P<0.01)。研究组的CR、PR、SD、PD、肝区疼痛缓解率、生活质量评分、无进展生存亦均高于对照组(均P<0.05)。结论 瘤体内注射榄香烯乳注射液治疗肝癌有较好疗效。
Objective To evaluate the efficacy of intratumoral injection of Elemene emulsion in treatment of liver cancer.Methods Fifty-nine patients with liver cancer were assigned to receive ultrasound-guided intratumoral injection of Elemene emulsion (study group, n=26) or intravenous infusion of Elemene emulsion (control group, n=33).The tumor size and quality of life in both groups were evaluated after 3 cycles of treatment (21 d per cycle).Results Compared with control group, the rates of mass reduction and mass echo enhancement in study group were both significantly higher (57.7%,76.9% vs 24.2%, 30.3%;both P<0.001).The reduction ratio of tumor blood flow signal, the reduction rate of tumor blood flow peak velocity and the decrease rate of tumor blood flow resistance index in study group were all significantly higher than those in control group (61.5%,34.6%, 34.6% vs 30.3%, 18.2%,21.2%;all P<0.01).C R, PR, SD, PD,liver pain remission rate, quality of life score and progression free survival in study group were all higher than those in control group(all P<0.05).Conclusion The efficacy of intratumoral injection of Elemene emulsion in treatment of liver cancer is satisfactory.
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