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中等剂量卡培他滨一线治疗激素受体阴性老年MBC的临床观察
作者:刘占伟  潘跃银 
单位:1. 淮南东方医院集团肿瘤医院肿瘤内科  安徽 淮南 232035 
2.
 安徽医科大学第一附属医院肿瘤内科  安徽 合肥 230022 
关键词:乳腺肿瘤/药物疗法 乳腺肿瘤/继发性 脱氧胞苷/投药和剂量 脱氧胞苷/类似物和衍生物 绝经期 治疗结果 随访研究 
DOI:R737.9;R730.53
出版年,卷(期):页码:2015,30(3):268-270
摘要:
目的 评估中等剂量卡培他滨单药一线治疗激素受体阴性老年女性转移性乳腺癌(metastatic breast cancer,MBC)的疗效和安全性。方法 32例初治激素受体阴性老年女性MBC患者,口服卡培他滨2000 mg/(m2·d),分早、晚2次,餐后服用,连续服用2周,休息1周,为1个周期,服药 ≥2周期。结果 32例患者共完成204周期的化疗,其中CR 1例(3.1%),PR 10例(31.3%),RR为34.4%(95%CI:18.6%~53.2%),DCR为87.5%(95%CI:71.0%~96.5%)。卡培他滨治疗乳腺癌软组织转移及肝、肺转移的疗效差异无统计学意义(P=1.0)。常见的不良反应是手足综合征。至随访结束,中位TTP为8.5月,中位OS为17.5月。结论 单药卡培他滨在老年女性初治MBC患者中较为有效且耐受性良好。
Objective To evaluate the efficacy and safety of moderate-dose capecitabine as first-line chemotherapy in elderly female patients with hormone receptor-negative metastatic breast cancer. Methods Thirty-two elderly female patients with hormone receptor-negative metastatic breast cancer were treated with capecitabine, 2 000 mg/(m2·d) for two weeks, after one-week interval, the course was repeated. All patients completed ≥2 courses. Results A total of 204 courses were completed in 32 patients. One patient (3.1%) achieved complete remission, 10 patients (31.3%) had partial remission, with response rate of 34.4%(95% CI:18.6%~53.2%) and disease control rate of 87.5%(95% CI:71.0%~96.5%). There is no difference in the efficacy of capecitabine treatment of liver and lung metastases and soft tissue metastases of breast cancer (P=1.0). The most common adverse event was hand-foot syndrome (HFS). The median time to progression was 8.5 months, and the overall survival time was 17.5 months. Conclusion Capecitabine is effective and well-tolerated as first-line treatment for elderly female patients with hormone receptor-negative metastatic breast cancer.
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