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TACE联合中药综合治疗原发性肝癌疗效分析
作者:靳同孝 
单位:泰安市肿瘤防治院影像特检科  山东 泰安 271000 
关键词:肝肿瘤/治疗 抗肿瘤剂(中药) 抗肿瘤药(中药) 综合疗法 肝动脉 输注 动脉内 化学栓塞 治疗性 生活质量 临床对照试验 
DOI:R735.7;R730.5
出版年,卷(期):页码:2015,30(5):444-447
摘要:
目的 观察中药制剂对经皮肝动脉插管化疗栓塞(transcatheter arterial chemoembolization,TACE)治疗后原发性肝癌患者生活质量的影响。方法 将106例原发性肝癌患者分成治疗组与对照组各53例,两组患者均采用TACE治疗,治疗组加用疏肝健脾解毒方治疗,观察两组近期疗效、卡氏评分、体质量的变化、食欲和睡眠的改善及不良反应情况。结果 治疗组总有效率为66.0%(35/53),低于对照组的67.9%(36/53),但差异无统计学意义(P=0.787)。生活质量及卡氏评分,治疗组优于对照组(P<0.05)。治疗后治疗组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论 疏肝健脾解毒方剂联合肝癌介入(TACE)治疗后能够改善原发性肝癌患者临床症状,减轻化疗药物的不良反应,提高生活质量。
Objective To investigate the efficacy of transcatheter arterial chemotherapy and embolization (TACE) combined with traditional Chinese medicine for patients with primary liver cancer. Methods One-hundred-and-six patients with primary liver cancer undergoing TACE were divided into 2 groups with 53 cases in each group. Test group received additional traditional Chinese medicine;control group received TACE only. Efficacy, Karnofsky performance scores, body weight change, adverse reactions and the improvement of appetite and sleep were observed in two groups. Results There was no significant difference in the overall response rate between test group and control group (66.0% vs 67.9%, P=0.787). Test group was better in Karnofsky score (P<0.05). The incidence of adverse reactions in test group was significantly less than that in control group (P<0.05). Conclusion Traditional Chinese medicine can relieve clinical symptoms, reduce side effects of chemotherapy and improve the quality of life for liver cancer patients undergoing TACE treatment.
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