首页365bet娱乐官网网址365bet国际娱乐城365bet体育在线官电子期刊下载专区广告合作征稿启事留言板
位置:首页 >> 电子期刊 >> 正文
肝细胞癌中eIF3h的表达及其临床意义
作者:王亚娟  鲁萍  刘曼 
单位:嵊州市人民医院病理科  浙江 绍兴 312400 
关键词: 肝细胞/病理学 免疫组织化学 蛋白质生物合成 真核细胞起始因子类 预后 
DOI:R735.7;R730.23
出版年,卷(期):页码:2017,32(4):345-348
摘要:

目的 探讨肝细胞癌(hepatocellular carcinoma,HCC)组织中真核起始因子3h(eukaryotic initiation factor 3h,eIF3h)的表达及其与临床病理特征的关系和对HCC预后的意义。方法 应用免疫组织化学法检测90例HCC及55例癌旁肝组织中eIF3h的表达。结果 eIF3h在HCC组织中的表达水平高于癌旁组织,差异具有统计学意义(P<0.01)。eIF3h高表达与低表达组在肿瘤分化程度、包膜侵犯及脉管浸润方面比较差异均具有统计学意义(均P<0.05)。eIF3h高表达HCC患者5年生存期短于低表达患者(P<0.01)。结论 eIF3h可能参与HCC的发生及发展,可以作为HCC预后的标志物。

365bet娱乐官网网址

Objective To investigate the expression of eukaryotic initiation factor 3h (eIF3h) in hepatocellular carcinoma (HCC) tissues,and to examine its relationship with the clinical characteristics and disease prognosis. Methods The expression of eIF3h was analyzed in 90 samples of HCC tissues and 55 samples of adjacent non-tumor tissues by immunohistochemistry. Results The expression of eIF3h in HCC tissues was higher than that in adjacent non-tumor tissues (P<0.01).There were significant differences in tumor differentiation,extracapsular tumor extension and vessel invasion between patients with high eIF3h expression and those with low eIF3h expression (all P<0.05).Moreover,patients with high eIF3h levels showed lower 5-year disease-free survival compared to patients with low eIF3h levels (P<0.01). Conclusion eIF3h may be involved in the development and differentiation of HCC,and can be used as a biomarker for HCC prognosis.

文章下载】【加入收藏

浙ICP备18004413号

技术服务qq:1507079184(投稿系统问题可找我)

编辑部地址:浙江省杭州市上城区解放路88号(浙医二院内)

电话:0571-87783654 邮编:310009 E-mail:shyzhl@zju.edu.cn

期刊介绍 使用帮助 | 365bet体育在线官 | 留言板