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子宫内膜癌患者血脂代谢临床分析
作者:曾秋平  曾剑兵  方秀兰 
单位:深圳市龙华区人民医院妇产急诊科  广东 深圳 518109 深圳市龙华区人民医院影像科  广东 深圳 518109 深圳市龙华区人民医院住院部儿科  广东 深圳 518109 
关键词:子宫内膜肿瘤/诊断 代谢综合征X 血脂异常/代谢 血脂异常/血液 甘油三酯类 胆固醇 脂蛋白类 HDL 脂蛋白类 LDL 
DOI:R737.33;R730.4
出版年,卷(期):页码:2018,33(2):158-161
摘要:

目的 分析子宫内膜癌患者血脂异常代谢情况。方法 收集子宫内膜癌患者56例作为子宫内膜癌组,选择同期门诊健康体检的56例女性作为对照组,两组均行血糖、血压、体质量指数(body mass index,BMI)和血脂四项等常规检查,分析血脂异常代谢与子宫内膜癌发生和发展的相关性。结果 与对照组比较,子宫内膜癌组糖尿病、高血压、高血脂以及超重与肥胖等慢性疾病的发病率均升高(均P<0.05)。子宫内膜癌组总胆固醇(cho-lestrol,CHOL)、甘油三酯(triglyceride,TG)和低密度脂蛋白(low density lipoprotein-cholesterol,LDL-C)均高于对照组(均P<0.01),而高密度脂蛋白(high density lipoprotein-cholesterol,HDL-C)低于对照组(P<0.01)。对血脂检测指标进行多因素Logistic回归分析,提示CHOL、TG、LDL-C和HDL-C均为子宫内膜癌发生的危险因素(均P<0.05)。结论 血脂异常代谢是子宫内膜癌发病的危险因素之一。

Objective To analyze the blood lipid metabolism in patients with endometrial carcinoma. Methods Fifty-six patients with endometrial cancer were collected as endometrial cancer group, and 56 healthy women who received outpatient health examination during the same time period were selected as control group. Blood glucose, blood pressure, body mass index (BMI) and blood lipids were measured in both groups. Routine examinations were performed to analyze the relationship between dyslipidemia metabolism and the occurrence and development of endometrial cancer. Results Compared with the control group, the incidences of chronic diseases such as diabetes, hypertension, hyperlipidemia, overweight, and obesity were increased in the endometrial cancer group (all P<0.05). In the endometrial cancer group, the levels of total cholesterol (CHOL), triglyceride (TG) and low density lipoprotein (LDL-C) were higher than those in the control group (all P<0.01). However, high-density lipoprotein-cholesterol (HDL-C) level was lower than that of the control group (P<0.01). Multivariate logistic regression analysis of blood lipid detection indicators revealed that CHOL, TG, LDL-C, and HDL-C were all risk factors for endometrial cancer (all P<0.05). Conclusion Abnormal blood lipid metabolism is a risk factor of endometrial cancer.

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