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老年结直肠癌的临床病理特征和预后
作者:杨姣  傅健飞  谭伊诺  蒋梦婕  文飞  袁瑛 
单位:西安交通大学附属第一医院肿瘤内科  陕西 西安 710061 金华市中心医院肿瘤内科  浙江 金华 321001 浙江大学医学院附属第二医院肿瘤内科  浙江 杭州 310009 浙江省中医院放疗科  浙江 杭州 310002 浙江大学医学院附属第二医院肿瘤研究所  浙江 杭州 310009 
关键词:结直肠肿瘤 外科学 预后 回顾性研究 
DOI:R735.3
出版年,卷(期):页码:2018,33(3):228-233
摘要:

目的 分析老年结直肠癌的临床病理特征和预后。方法 回顾性分析经术后病理确诊为结直肠腺癌的2 460例患者的临床资料。比较老年组(≥ 70岁)和年轻组(<70岁)的临床病理特征和术后生存情况。结果 2 460例患者中位年龄59岁,老年组544例(22.1%),年轻组1 916例(77.9%)。老年结直肠癌患者以男性、结肠部位和管状腺癌多见(均P<0.05),远处转移较少(P=0.008),但接受姑息术治疗的比例高(P=0.005)。老年组和年轻组的术后10年总生存比较,差异无统计学意义(P=0.601)。Ⅱ期疾病患者中,老年组术后5年总生存率较年轻组差(P=0.008)。结论 老年结直肠癌患者的术后总生存不差于年轻患者。Ⅱ期患者中,老年患者预后较差。

Objective To analyze the clinicopathological characteristics and prognosis of elder patients with colorectal cancer.Methods The clinical data of 2 460 cases of pathologically diagnosed colorectal cancer patients were studied retrospectively. The clinical characteristics and postoperative survival rates were compared between the elder group (≥ 70 years old) and young group (<70 years old).Results Among all patients, the median age was 59 years old, with 544 (22.1%) patients categorized in the elder group and 1 916 (77.9%) cases categorized in the young group. In the elder group, there were more cases of male patients, colon tumors and tubular adenocarcinoma (all P<0.05), fewer cases of long distance metastasis (P=0.008), and more cases of palliative surgery (P=0.005). However, no significant diffe-rence was found on the 10-year overall survival rates between the elder and the young groups (P=0.601). Nevertheless, among stage Ⅱ patients, the 5-year overall survival rate was lower in the elder group than that in the young group (P=0.008).Conclusion The overall postoperative survival rates were comparable between the elder and the young colorectal cancer patients, but stage Ⅱ elder patients had poor prognosis.

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