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腹腔热灌注化疗治疗结直肠癌腹膜转移癌临床疗效的meta分析
作者:黄思澔  杨朝纲  姜军  熊斌 
单位:武汉大学中南医院胃肠外科  湖北 武汉 430071 
关键词:结直肠肿瘤/药物疗法 腹膜肿瘤/继发性 腹膜肿瘤/药物疗法 高温 诱发 化学疗法 肿瘤 局部灌注 治疗结果 meta分析 
DOI:10.13267/j.cnki.syzlzz.2018.06.006
出版年,卷(期):页码:2018,33(6):524-528
摘要:

目的 探讨腹腔热灌注化疗(hyperthermic intraperitoneal chemotherapy,HIPEC)治疗结直肠癌腹膜转移癌的疗效和安全性。方法 检索2000年1月至2017年1月间在英文数据库(Embase、PubMed、Web of Science和Scopus)和中文数据库(知网、万方和维普)发表的比较结直肠癌腹膜转移癌治疗方法的文献。以行细胞减灭术加HIPEC的患者为治疗组,行手术治疗或全身化疗的患者为对照组。采用Stata12.0软件进行统计学分析,比较两组患者的3年和5年生存率以及治疗安全性。结果 纳入9项研究共1 941例患者,其中治疗组1 200例,对照组741例。综合分析显示,治疗组3年生存率(OR=5.48,95%CI:4.36~6.87,P<0.01)和5年生存率(OR=5.57,95%CI:4.29~7.23,P<0.01)均高于对照组。结论 结直肠癌腹膜癌患者细胞减灭术加HIPEC可以提高生存率,改善患者预后。

Objective To investigate the efficacy and safety of hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of peritoneal carcinomatosis form colorectal cancer. Methods We searched for literature focusing on comparison of treatment methods for peritoneal carcinomatosis form colorectal cancer and published from January 2000 to January 2017 in databases such as PubMed,Embase,Web of Science,Scopus,CNKI,Wanfang and VIP database. Patients receiving HIPEC following cytoreductive surgery were selected as treatment group,while patients who received surgery/systemic chemotherapy were used as control group. 3-year and 5-year survival and safety of the treatment methods of the two groups were compared. Results A total of 1 941 patients from 9 studies were included in this study,of them 1 200 were in treatment group and 741 in control group. Pooled analysis showed that 3-year (OR=5.48,95% CI:4.36-6.87,P<0.01) and 5-year (OR=5.57,95% CI:4.29-7.23,P<0.01) survival of treatment group were significantly improved compared with control group. Conclusion Cytoreductive surgery combined with HIPEC treatment significantly improved survival of patients with peritoneal carcinomatosis form colorectal cancer,and improved the prognosis of patients.

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