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葡萄糖转运蛋白-1在横纹肌肉瘤中的表达及临床意义
作者:李娟  陈广生  安鲁  刘燕飞  石国英 
单位:西安市儿童医院病理科  陕西 西安 710003 陕西省中医医院病理科  陕西 西安 710003 
关键词:横纹肌肉瘤 葡萄糖转运蛋白-1 免疫组织化学 
DOI:10.13267/j.cnki.syzlzz.2018.06.008
出版年,卷(期):页码:2018,33(6):533-536
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摘要:

目的 探讨葡萄糖转运蛋白-1(glucose transporter-1,Glut-1)在横纹肌肉瘤中的表达及临床意义。方法 收集经病理学证实的53例横纹肌肉瘤患者的临床资料及组织标本,应用免疫组织化学法检测肿瘤组织及对应肿瘤旁正常组织中Glut-1的表达情况,并对随访和临床病理资料进行统计分析。结果 横纹肌肉瘤组织和肿瘤旁正常组织中Glut-1的表达分别为4.27±0.26和3.72±0.17(P<0.05)。Glut-1阳性表达的横纹肌肉瘤患者中位生存时间短于阴性表达患者(33.4个月vs 47.1个月,P=0.011)。Glut-1的表达阳性率在病理分期、病理分型、肿瘤大小和淋巴结转移情况方面比较,差异均具有统计学意义(均P<0.05)。结论 Glut-1在横纹肌肉瘤的发生和发展中具有重要作用,可以作为一个潜在的靶点用于肿瘤的早期诊断和预后分析。

Objective To evaluate the expression of glucose transporters (Glut-1) in rhabdomyosarcoma and its clinical significance. Methods The clinical data and tissue samples of 53 cases of pathologically confirmed rhabdomyosarcoma patients were collected.Immunohistochemical method was used to detect the expression level of Glut-1 in tumor tissues and adjacent normal tissues.Statistical analyses were then performed for the follow-up and clinicopathological data. Results The expression level of Glut-1 in the tumor tissues and paracancerous tissues were 4.27 ±0.26 and 3.72 ±0.17,respectively (P<0.05).Moreover,the median survival time of Glut-1 positive rhabdomyosarcoma patients was significantly shorter than that of Glut-1 negative patients (33.4 months vs 47.1 months,P=0.011).Finally,positive expression of Glut-1 was significantly correlated with pathological stages,pathological types,tumor sizes and lymph node metastasis(all P<0.05). Conclusion Glut-1 may participate in the occurrence and development of rhabdomyosarcoma,which is expected to become a potential research target for the early diagnosis and disease prognosis of rhabdomyosarcoma.

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