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恩度联合顺铂腔内注射治疗肺癌合并恶性胸腔积液meta分析
作者:周燕群  郭勇  杨笑奇 
单位:浙江中医药大学第一临床医学院  浙江 杭州 310053 浙江中医药大学附属第一医院肿瘤内科  浙江 杭州 310006 浙江邵逸夫医院中医科  浙江 杭州 310016 
关键词:肺肿瘤 恩度 顺铂 恶性胸腔积液 meta分析 
DOI:10.13267/j.cnki.syzlzz.2018.06.012
出版年,卷(期):页码:2018,33(6):553-560
摘要:

目的 系统评价恩度联合顺铂腔内注射治疗肺癌合并恶性胸腔积液的疗效及安全性。方法 计算机检索PubMed、The Cochrane Library、Embase、Web of Science、CNKI、Wan Fang Data、VIP和CBM数据库,检索恩度联合顺铂腔内注射治疗肺癌合并恶性胸腔积液的相关文献,筛选文献、提取数据并对纳入研究进行质量评价后,用RevMan 5.2软件进Meta分析。结果 共纳入25项RCT研究,共1 577例患者。恩度联合顺铂治疗肺癌合并恶性胸腔积液的总有效率(RR=1.54,95%CI:1.43~1.66;Z=11.16,P<0.01)和生活质量改善率(RR=1.60,95%CI:1.44~1.78;Z=8.60,P<0.01)高于单药顺铂,但两者在骨髓抑制、消化道反应、肝肾功能异常、发热、疲劳和心脏毒性等主要不良反应方面比较,差异均无统计学意义(均P>0.05)。结论 恩度联合顺铂腔内注射治疗肺癌合并恶性胸腔积液,能提高总有效率,改善患者生活质量,具有良好的安全性。

Objective To systematically review the efficacy and safety of Endostar combined with cisplatin for the treatment of lung cancer complicated with malignant pleural effusion. Methods PubMed,The Cochrane Library,Embase,Web of Science,CNKI,Wan Fang Data,VIP and CBM were search for related literatures of Endostar combined with cisplatin for treating lung cancer with malignant pleural effusion. We screened the literature,extracted data and evaluated the quality of included studies. Meta-analysis was performed by using RevMan 5.2 software. Results<365bet娱乐官网网址/b> A total of 25 RCTs involving 1 577 participants were included. As a result,our analysis indicated that for lung cancer with malignant pleural effusion,Endostar combined with cisplatin therapy achieved significantly improved treatment efficacy (RR=1.54,95% CI:1.43-1.66;Z=11.16,P<0.01) and the quality of life (RR=1.60,95% CI:1.44-1.78;Z=8.60,P<0.01),as compared with cisplatin single therapy. Moreover,the two groups showed no significant difference in the incidence of adverse effects,including bone marrow suppression,gastrointestinal reaction,abnormal renal and liver function,fever,fatigue,and cardiotoxicity (all P>0.05). Conclusion Combined intrapleural injection of Endostar and cisplatin can safely improved the overall response and the life quality of lung cancer patients complicated with malignant pleural effusion.

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