首页365bet娱乐官网网址365bet国际娱乐城365bet体育在线官电子期刊下载专区广告合作征稿启事留言板
位置:首页 >> 电子期刊 >> 正文
细胞核中GS28蛋白表达对结肠癌患者术后预后的影响
作者:黄江  刘敏  陈绪阳  魏晴 
单位:延安大学附属医院普外科  陕西 延安 716000 延安大学附属医院肿瘤科  陕西 延安 716000 商洛市中心医院肿瘤内科  陕西 商洛 726000 延安大学附属医院消化内科一病区  陕西 延安 716000 
关键词:结肠肿瘤/病理学 高尔基体 SNARE蛋白质类 基因 erbB-1 基因表达 预后 免疫组织化学 
DOI:10.13267/j.cnki.syzlzz.2018.06.014
出版年,卷(期):页码:2018,33(6):565-569
摘要:

目的 探讨结肠癌患者细胞核高尔基体受体复合物1(Golgi SNAP receptor complex 1,GS28)蛋白的表达情况以及对术后预后的影响。方法 选取350例结肠癌患者作为研究对象,免疫组织化学法分析细胞核中GS28蛋白的表达情况。根据是否主要表达在细胞核,分为核优势表达组(n=48)和非核优势表达组(n=302)。比较两组患者的临床病理特征,分析细胞核GS28蛋白表达水平与鼠类肉瘤病毒癌基因(kirsten rat sarcoma viral oncogene,KRAS)突变及表皮生长因子受体(epidermal growth factor receptor,EGFR)表达水平相关性,并采用Kaplan-Meier法分析两组患者的总体生存期。结果 本组350例中,GS28蛋白在细胞核中优势表达48例(13.7%)。GS28核优势表达组和非核优势表达组患者在T分期和神经浸润方面比较,差异均具有统计学意义(均P<0.05)。相关性分析显示,细胞核GS28蛋白表达水平与KRAS突变及EGFR表达水平均无相关性(P=0.924,P=0.126)。GS28核优势表达组患者中位生存期低于非核优势表达组(62个月vs 77个月,P<0.05)。结论 GS28蛋白细胞核优势表达影响结肠癌患者的总体生存期,可以考虑作为潜在的预后标志物。

Objective To investigate the expression of nuclear Golgi SNAP receptor complex 1 (GS28) protein and its impacts on the postoperative survival of colon cancer patients. Methods Three-hundred-and-fifty colon cancer patients were recruited. The level of nuclear GS28 protein expression were examined by pathological and immunohistochemical analysis.According to whether mainly expressed in the nucleus,the patients were divided into nuclear predominant group(n=48) and non nuclear predominant group (n=302). The clinical data and the relation between GS28 protein expression in the nuclear and mutation of kirsten rat sarcoma viral oncogene (KRAS) and epidermal growth factor receptor (EGFR) expression were analyzed. The overall survival was analyzed with the Kaplan-Meier method. Results Among the 350 cases,48 cases has nuclear predominant GS28 expression (13.7%);and there were statistically significant differences in the data about neural invasion and T stage between the nuclear predominant group and non-nuclear predominant group (both P<0.05). Correlation analysis showed that there was no correlation between GS28 protein expression in the nuclear and KRAS mutation or EGFR expression level(P=0.924,P=0.126). The median survival time of nuclear predominant group was significantly lower than that of non-nuclear predominant group (62 months vs 77 months, P<0.05). Conclusion The nuclear dominance expression of GS28 protein affects the overall survival of colon cancer patients,and can be used as a potential prognostic marker.

文章下载】【加入收藏

浙ICP备18004413号

技术服务qq:1507079184(投稿系统问题可找我)

编辑部地址:浙江省杭州市上城区解放路88号(浙医二院内)

电话:0571-87783654 邮编:310009 E-mail:shyzhl@zju.edu.cn

期刊介绍 使用帮助 | 365bet体育在线官 | 留言板