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缩宫素在高强度聚焦超声治疗子宫肌瘤中的应用研究
作者:范清秋  卢彬  祝一颖  胡晓晔&n365bet娱乐官网网址bsp;
单位:浙江大学医学院附属第二医院门诊护理  浙江 杭州 310009 浙江大学医学院附属第二医院肿瘤外科  浙江 杭州 310009 
关键词:子宫肿瘤/治疗 超声 高强聚焦 经肠 超声疗法/方法 平滑肌瘤/治疗 催产素/治疗应用 治疗结果 安全 
DOI:10.13267/j.cnki.syzlzz.2018.06.015
出版年,卷(期):页码:2018,33(6):570-573
摘要:

目的 探讨术中应用缩宫素在高强度聚焦超声治疗子宫肌瘤中的短期有效性及安全性。方法 回顾性分析应用高强度聚焦超声治疗子宫肌瘤的病例,其中术中未使用缩宫素48例(无缩宫素组),术中应用缩宫素(0.18 U/min)62例(缩宫素组)。术后1周门诊复查及子宫MRI增强扫描评估治疗效果。比较两组消融效率、单位体积消融时间以及临床不良反应的发生率。结果 缩宫素组和无缩宫素组消融效率分别为(51.8±2.5)%和(69.5±2.1)%(P<0.01),单位体积消融时间分别为(1.72±0.37)min和(0.37±0.10)min(P<0.01)。两组疼痛评分、皮肤烫伤、术后低热和少量阴道出血等轻度不良反应发生率比较,差异均无统计学意义(均P>0.05),均未出现空腔脏器穿孔等严重不良反应。结论 使用缩宫素能提高高强度聚焦超声治疗子宫肌瘤患者的短期消融效率,缩短术中治疗时间,且不增加不良反应发生率。

Objective To investigate the short-term efficacy and safety of intraoperative usage of oxytocin in uterine leiomyoma patients treated by high intensity focused ultrasound (HIFU). Methods One-hundred-and-ten patients with uterine leiomyoma were enrolled in the study,including 48 cases treated with HIFU alone (control group),and 62 cases treated with HIFU and intraoperative administration of oxytocin (0.18 U/min,oxytocin group). The treatment effect was evaluated by outpatient review and pelvic enhanced MRI one week after procedure. The ablation efficiency,unit-volume ablation time and clinical adverse reactions were compared between the two groups. Results In the control group and the oxytocin group,the ablation efficiency was (51.8±2.5)% and (69.5±2.1)% (P<0.01),and the unit-volume ablation time was (1.72±0.37)min and (0.37±0.10)min (P<0.01), respectively. Besides,no significant difference was observed in the incidence of mild adverse reactions between the two groups,such as pain score,skin scald,postoperative fever and vaginal bleeding (all P>0.05). Serious adverse reactions such as intestinal perforation were not observed in any case. Conclusion The usage of oxytocin improves the short-term ablation efficiency,shortens the treatment time without increasing the incidence of adverse reactions in uterine leiomyoma patients treated by HIFU.

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