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胸腺瘤STAT3表达临床意义分析
作者:史金胜  刘美芹  温静静  陈红芳  宗佩君  张云香 
单位:潍坊市益都中心医院病理科  山东 潍坊 262500 潍坊市人民医院病理科  山东 潍坊 261041 
关键词:胸腺肿瘤/病理学 胸腺肿瘤/分类 胸腺瘤/病理学 STAT3转录因子 基因表达 预后 免疫组织化学 随访研究 
DOI:10.13267/j.cnki.syzlzz.2019.01.005
出版年,卷(期):页码:2019,34(1):27-30
摘要:

目的 研究胸腺瘤组织中信号转导和转录激活因子3 (signal transducer and activators of transcription 3,STAT3)表达情况及其与临床病理特征以及预后的关系。方法 收集随访>5年的胸腺瘤患者手术切除肿瘤组织85例以及正常胸腺组织24例为对照。应用免疫组织化学SP法检测组织中STAT3的表达情况。分析其与胸腺瘤临床病理特征及与复发和生存情况的关系。结果 STAT3在胸腺瘤中的表达阳性率为49.4%,高于对照组的25.0%(P=0.033)。STAT3在胸腺瘤中的表达在肿瘤病理类型、肿瘤分期、复发情况和生存情况方面比较,差异均具有统计学意义(均P<0.01),而在性别和年龄方面比较,差异均无统计学意义(均P>0.05)。结论 STAT3在B型胸腺瘤及胸腺癌中的表达高于A型和AB型胸腺瘤,与患者复发及预后有关。

Objective To study the expression of signal transducer and activators of transcription 3(STAT3) in thymoma and analyze its relationship with the clinicopathological features and prognosis of the patients. Methods Tumor tissues from 85 thymoma patients who underwent tumor dissection surgery and were followed up for more than 5 years were collected. Twenty-four normal thymus tissue samples were included as the control group.The expression of STAT3 was detected in the sample tissues by immunohistochemical SP method.The influences of STAT3 expression on the clinicopathological features,recurrence rates and survival rates of thymoma were further analyzed. Results The positive rate of STAT3 expression in thymoma was 49.4%,which was significantly higher than the 25.0% postive expression in the control group(P=0.033).Moreover,STAT3 expression was significantly related to tumor pathological types,tumor stage,recurrence and survival in thymomas(all P<0.01),but not related to gender or age(both P>0.05). Conclusion The expression of STAT3 in type B thymoma and thymic carcinoma is higher than those in type A and type AB thymoma,which is related to the recurrence and prognosis of patients.

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