首页365bet娱乐官网网址365bet国际娱乐城365bet体育在线官电子期刊下载专区广告合作征稿启事留言板
位置:首页 >> 电子期刊 >> 正文
影响ⅠB~ⅡB期子宫颈癌预后的相关因素分析
作者:庹菲  蔡红兵  王志强 
单位:武汉大学中南医院妇瘤科  湖北省肿瘤医学研究中心  肿瘤生物学行为湖北省重点实验室  湖北 武汉 430071 华中科技大学同济医学院附属武汉市中心医院妇产科  湖北 武汉 430071 
关键词:宫颈肿瘤 危险因素 存活率分析 预后 回顾性研究 
DOI:10.13267/j.cnki.syzlzz.2019.01.006
出版年,卷(期):页码:2019,34(1):31-34
摘要:

目的 探讨影响ⅠB~ⅡB期子宫颈癌患者预后的相关因素。方法 回顾性分析随访资料完整的ⅠB~ⅡB期子宫颈癌患者215例。Kaplan-Meier法计算疾病相关生存期,单因素及多因素回归分析探讨临床病理特征与总生存的关系。结果 所有患者中位随访时间为108.8(12.0~156.0)个月。单因素分析显示,年龄(P=0.007)、肿瘤大小(P=0.012)、国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)分期(P<0.01)、手术切缘受累(P=0.013)、宫旁受累(P=0.007)、淋巴结转移(P<0.01)和单纯手术治疗方式(P=0.004)为影响预后的主要因素。患者总生存期在组织学类型(P=0.318)、病灶生长方式(P=0.732)、组织分化程度(P=0.276)和间质浸润深度(P=0.066)方面比较,差异均无统计学意义。Cox回归分析显示,肿瘤大小(RR=1.76,95%CI:1.05~2.97,P=0.033)、FIGO分期(RR=2.14,95%CI:1.47~3.11,P<0.01)及淋巴结转移(RR=2.28,95%CI:1.41~3.72,P=0.001)为子宫颈癌预后的独立危险因素。结论 影响ⅠB~ⅡB期子宫颈癌预后的因素为年龄、肿瘤大小、FIGO分期、手术切缘受累、宫旁受累、淋巴结转移和治疗方式,其中肿瘤大小、FIGO分期和淋巴结转移为独立危险因素。

Objective To investigate the prognosis factors of patients with stage ⅠB-ⅡB cervical cancer. Methods Two-hundred-and-fifteen patients with stage ⅠB-ⅡB cervical cancer and complete follow-up data were retrospectively analyzed. The Kaplan-Meier method was used to calculate disease-related survival. Univariate and multivariate regression analysis were used to investigate the relationship between clinical pathological features and overall survival. Results T365bet娱乐官网网址he median follow-up time for all patients was 108.8 (12.0-156.0) months. Univariate analysis showed age (P=0.007),tumor diameter (P=0.012),International Federation of Gynecology and Obstetrics(FIGO) stage (P<0.01),surgical margin involvement (P=0.013),parametrial involvement (P=0.007),lymph node metastasis (P<0.01) and surgery alone (P=0.004) were the main factors affecting the prognosis. The overall survival of the patients was not statistically significant in histological types (P=0.318),lesion growth patterns (P=0.732),histological differentiation (P=0.276) and interstitial infiltration depth (P=0.066).Cox regression analysis showed tumor diameter (RR=1.76,95% CI:1.05-2.97,P=0.033),FIGO stage (RR=2.14,95% CI:1.47-3.11,P<0.01) and lymph node metastasis (RR=2.28,95% CI:1.41-3.72,P=0.001) were independent risk factors for the prognosis of cervical cancer. Conclusion The factors affecting the prognosis of stage ⅠB-ⅡB cervical cancer include age of onset,size of tumor,FIGO stage,involvement of surgical margins,parametrial invasion,lymph node metastasis and treatment options,of which tumor diameter,FIGO stage and lymph node metastasis are independent risk factors.

文章下载】【加入收藏

浙ICP备18004413号

技术服务qq:1507079184(投稿系统问题可找我)

编辑部地址:浙江省杭州市上城区解放路88号(浙医二院内)

电话:0571-87783654 邮编:310009 E-mail:shyzhl@zju.edu.cn

期刊介绍 使用帮助 | 365bet体育在线官 | 留言板