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CD147及MMP-7在胆管癌中的表达及其临床意义
作者:王志凯  张超  白军伟  张辉  田鹏 
单位:河南省人民医院胃肠外科三病区  河南 郑州 450003 
关键词:胆管肿瘤/病理学 胆管肿瘤/诊断 基质金属蛋白酶-7 膜糖蛋白类 基因表达 预后 免疫组织化学 
DOI:10.13267/j.cnki.syzlzz.2019.01.007
出版年,卷(期):页码:2019,34(1):35-38
摘要:

目的 探讨细胞表面糖蛋白酶诱导体cluster of differentiation 147(CD147)和基质金属蛋白酶-7(matrix metalloproteinase-7,MMP-7)在胆管癌组织中的表达及与临床病理特征的关系。方法 选取行手术切除胆管癌且病理证实的109例患者的胆管癌组织为胆管癌组,同期行胆管癌根治术的100例患者的癌旁正常胆管组织标本为对照组。采用Image-pro Plus 6.0图像分析和免疫组织化学实验检测CD147和MMP-7在组织中的表达。结果 胆管癌组细胞表面CD147和MMP-7的PU值均高于对照组,差异均具有统计学意义[(33.9±9.4)PU vs (12.3±4.3)PU,(57.5±15.4)PU vs (12.2±2.5)PU,均P<0.01]。CD147和MMP-7表达在胆管癌患者性别、年龄和有无神经侵犯方面比较,差异均无统计学意义(均P>0.05),而在浸润深度、病理分化程度及TNM分期方面比较,差异均具有统计学意义(均P<0.05)。结论 CD147和MMP-7在胆管癌组织中高表达,且与胆管癌浸润深365bet娱乐官网网址度、病理分化程度及TNM分期有关。

Objective To investigate the expression of cluster of differentiation 147 (CD147) and matrix metalloproteinase-7 (MMP-7) in cholangiocarcinoma and their relationships with the clinicopathological features of cholangiocarcinoma patients. Methods Tumor tissue samples from 109 patients who underwent surgical resection and were pathologically confirmed as cholangiocarcinoma were collected as the cholangiocarcinoma group.Besides,the specimens of adjacent normal bile duct tissues of 100 patients who underwent cholangiocarcinoma radical surgery during the same time period were included as the control group.Image-pro Plus 6.0 image analysis and immunohistochemistry experiments were used to detect the expressions of CD147 and MMP-7 in tissues. Results The PU values of the cell surface CD147 and MMP-7 of the cholangiocarcinoma group were significantly higher than those of the control group[CD147:(33.9±9.4)PU vs (12.3±4.3)PU,MMP-7:(57.5±15.4)PU vs (12.2±2.5)PU,both P<0.01]. Moreover,as for their relationships with clinicopathological features,the expressions of CD147 and MMP-7 were significantly related to the infiltration depth,pathological differentiation and TNM staging (all P<0.05),but not related to gender,age or neurological invasion(all P>0.05). Conclusion CD147 and MMP-7 are highly expressed in cholangiocarcinoma tissues,and are related with the infiltration depth,pathological differentiation,and TNM stage of cholangiocarcinoma.

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