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胃癌血清肿瘤标志物和HER2表达的临床意义
作者:张蕾  薛永飞  冀叶  任中海 
单位:南阳市中心医院肿瘤内科  河南 南阳 473000 
关键词:胃肿瘤/病理学 胃肿瘤/诊断 免疫组织化学 受体 表皮生长因子 肿瘤标记 生物学/分析 肿瘤分期 回顾性研究 
DOI:10.13267/j.cnki.syzlzz.2019.01.013
出版年,卷(期):页码:2019,34(1):61-65
摘要:

目的 探讨血清肿瘤标志物及免疫组织化学指标与胃癌临床病理特征的关系。方法 回顾性分析经手术切除和病理确诊的胃腺癌患者90例,采用酶联免疫吸附测定法(enzyme linked immunosorbent assay,ELISA)检测糖链抗原724(carbohydrate antigen 724,CA724)、癌胚抗原(carcino embryonic antigen,CEA)、CA199和CA125水平,FISH法检测HER2表达,分析其与临床病理特征的关系。结果 Ⅳ期胃腺癌患者血清CEA和CA125水平较高(均P<0.05)。血清CA125水平在淋巴结转移方面比较,差异具有统计学意义(P<0.05)。CEA水平在肿瘤大小和淋巴结转移方面比较,差异均具有统计学意义(均P<0.05)。CA199水平在肿瘤大小和浸润深度方面比较,差异均具有统计学意义(均P<0.05)。CA724水平在肿瘤大小、浸润深度和淋巴结转移方面比较,差异均具有统计学意义(均P<0.05)。HER2表达在肿瘤大小和临床分期方面比较,差异均具有统计学意义(均P<0.05)。结论 血清肿瘤标志物和胃癌患者淋巴结转移、胃壁浸润深度及肿瘤大小有关,HER2表达和临床分期及肿瘤大小有关。

Objective To explore the relationship between clinicopathological features and the levels of serum tumor markers and immunohistochemical index in gastric cancer. Methods The data of 90 patients who underwent surgical resection and were pathological confirmed as gastric adenocarcinoma were retrospectively analyzed. 365bet娱乐官网网址Enzyme-linked immunosorbent assay (ELISA) was used to detect the level of carbohydrate antigen 724 (CA724),carcinoembryonic antigen (CEA),CA199 and CA125. Fluorescence in situ hybridization(FISH) was used to measure HER2 expression. Results Serum CEA and CA125 levels were increased in patients with stage Ⅳ gastric adenocarcinoma (all P<0.05).Besides,the level of serum CA125 was significantly related with lymph node metastasis (P<0.05). The level of CEA was significantly related with tumor size and lymph node metastasis (both P<0.05). The level of CA199 was significantly related with tumor size and infiltration depth (both P<0.05), and the level of CA724 was significantly related with tumor size,depth of invasion and lymph node metastasis (all P<0.05).Moreover,HER2 expression was also significantly related to tumor size and clinical stage (both P<0.05). Conclusion Serum tumor markers are associated with lymph node metastasis,depth of invasion of the stomach wall and tumor size,whereas the expression of HER2 was related to clinical stage and tumor size in gastric cancer.

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